5 NF-κB and AKT signaling prevent DNA damage by suppressing RAG1/2 | 139 Supplemental Table 2: B-ALL patient cytogenetic characteristics Patient Cytogenetic profile Other 1 53,XY,+X,+4,+6,+14,+17,+18,+21[2], add(16)(?q24) [4]/46,XY[14] BCR-ABL negative TEL-AML1 negative MLL-AF4 negative E2A-PBX1 negative ΔIKZF1 ex4-7 2 52~53,XY,+4,+9,+14,+17,+18,+21, +2~4mar,inc[cp8]/46,XY[12] BCR-ABL negative TEL-AML1 negative MLL-AF4 negative E2A-PBX1 negative ΔIKZF1 negative 3 Not available BCR-ABL negative TEL-AML1 negative T(11;v) MLL partner unknown Supplemental figures Supplemental Figure 1. Combined treatment with MLN120B and AKTi stimulates RAG activity in mouse Abl pre-B cells. Titration curve of MLN120B (circles + line) and titration of MLN120B + 2.5 mM AKTi (boxes + line). RAG-reporter activity (y-axis) of wildtype mouse Abl pre-B cells is plotted against the concentration of MLN120B (x-axis), cells were treated for 96h (n=4 independent cultures), means ± SD are shown.
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