5 NF-κB and AKT signaling prevent DNA damage by suppressing RAG1/2 | 143 Supplemental Figure 6. NF-kB gene expression signatures are associated with the expression of DNA replication pathway genes and white blood cell counts. (A) Heatmap showing expression of DNA replication pathway genes (Kyoto Encyclopedia of Genes and Genomes, KEGG). Each column represents a B-ALL patient. Yellow squares indicate NF-kB ‘low’ signature patients, purple squares indicate NF-kB ‘high’ signature patients. (B) White blood cell counts (x1000/microliter) in NF-kB ‘low’ and NF-kB ‘high’ signature B-ALL patients. Each circle represents an individual patient, grey bars indicate means. Below the graph the ANOVA F-statistic and p-value are given.
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