Katarina Ochodnicka

6 DNA damage-induced p53 downregulates expression of RAG1 | 165 Supplemental references 1. Pegoraro, L. et al. Establishment of a Ph1-positive human cell line (BV173). J. Natl. Cancer Inst. 70, 447–53 (1983). 2. Muljo, S. A. & Schlissel, M. S. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat. Immunol. 4, 31–7 (2003). 3. Shen, H. & Maki, C. G. Pharmacologic activation of p53 by small-molecule MDM2 antagonists. Curr. Pharm. Des. 17, 560–568 (2011). 4. Chae, H. J. et al. Molecular mechanism of staurosporine-induced apoptosis in osteoblasts. Pharmacol. Res. 42, 373–381 (2000). 5. Barlow, C. et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86, 159–171 (1996). 6. Donehower, L. A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215–221 (1992). 7. Bredemeyer, A. L. et al. ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature 442, 466–470 (2006). 8. Ochodnicka-Mackovicova, K. et al. NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity. Blood 126, 1324–1335 (2015). 9. van Keimpema, M. et al. The forkhead transcription factor FOXP1 represses human plasma cell differentiation. Blood 126, 2098–2109 (2015). 10. van Keimpema, M. et al. The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells. Haematologica 102, 573–583 (2017). 11. van Keimpema, M. et al. FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells. Blood 124, 3431–3440 (2014).

RkJQdWJsaXNoZXIy MTk4NDMw