3 RAG1/2 introduces double-stranded breaks at non-Ig loci | 65 Figure 4. Graphs showing the enrichment ratios of canonical RSS sequences (CACAGTG and ACAAAAACC) within RAG1/2-dependent NBS1 peaks, divided into 3 subsets: ‘all sequences’, ‘Igk only’ and in a subset where the Igk locus peaks were excluded (“no Igk”). The enrichment of canonical RSS sequences in these subsets was analyzed in sequences directly under NBS1 peaks (A), sequences extended by 500bp at each end (B), and sequences extended by 1000bp at each end (C).
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