Table of content Chapter 1 General introduction and outline of this thesis 9 Chapter 2 Role of RAG1 and RAG2 in B-cell development, signaling and (off) target DNA damage 15 Chapter 3 RAG1/2 induces double-stranded DNA breaks at non-Ig loci in the proximity of single sequence repeats in developing B cells 53 Chapter 4 The DNA damage response regulates RAG1/2 expression in pre-B cells through ATM-FOXO1 signaling 81 Chapter 5 NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity 115 Chapter 6 DNA damage-induced p53 downregulates expression of RAG1 though a negative feedback loop involving miR-34a and FOXP1 147 Chapter 7 General discussion 167 Appendix English summary 194 Nederlandse samenvatting 197 Zhrnutie v slovenčine 201 Authors’ contributions & Research funding 204 PhD portfolio & Publications 208 About the author 211 Acknowledgements 212
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