4 DNA damage response regulates RAG1/2 expression through ATM-FOXO1 | 91 damage-induced down-regulation of RAG1/2 mRNA transcripts in the BV173 and A70 cell lines and in primary mouse WT pre-B cells (Figures 1D-1G). In addition, expression of Rag1 mRNA in primary pre-B cells derived from Atm-/- mouse bone marrow remained unaffected by DNA damage (data not shown), supporting a central role for ATM kinase in the regulation of RAG1 expression following DNA damage.
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