I
219
Katarina Ochodnicka
Chapter 1 General introduction and outline of this thesis
9
Chapter 2 Role of RAG1 and RAG2 in B-cell development, signaling and (off) target DNA damage
15
Chapter 3 RAG1/2 induces double-stranded DNA breaks at non-Ig loci in the proximity of single sequence repeats in developing B cells
53
Chapter 4 The DNA damage response regulates RAG1/2 expression in pre-B cells through ATM-FOXO1 signaling
81
Chapter 5 NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity
115
Chapter 6 DNA damage-induced p53 downregulates expression of RAG1 though a negative feedback loop involving miR-34a and FOXP1
147
Chapter 7 General discussion
167
Appendix
193
English summary
194
Nederlandse samenvatting
197
Zhrnutie v slovenčine
201
Authors’ contributions & Research funding
204
PhD portfolio & Publications
208
About the author
211
Acknowledgements
212
Made with FlippingBook
RkJQdWJsaXNoZXIy MTk4NDMw