Katarina Ochodnicka

Chapter 1 General introduction and outline of this thesis 9
Chapter 2 Role of RAG1 and RAG2 in B-cell development, signaling and (off) target DNA damage 15
Chapter 3 RAG1/2 induces double-stranded DNA breaks at non-Ig loci in the proximity of single sequence repeats in developing B cells 53
Chapter 4 The DNA damage response regulates RAG1/2 expression in pre-B cells through ATM-FOXO1 signaling 81
Chapter 5 NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity 115
Chapter 6 DNA damage-induced p53 downregulates expression of RAG1 though a negative feedback loop involving miR-34a and FOXP1 147
Chapter 7 General discussion 167
Appendix 193
English summary 194
Nederlandse samenvatting 197
Zhrnutie v slovenčine 201
Authors’ contributions & Research funding 204
PhD portfolio & Publications 208
About the author 211
Acknowledgements 212

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