Katarina Ochodnicka

Chapter 1 General introduction and outline of this thesis	9
Chapter 2 Role of RAG1 and RAG2 in B-cell development, signaling and (off) target DNA damage	15
Chapter 3 RAG1/2 induces double-stranded DNA breaks at non-Ig loci in the proximity of single sequence repeats in developing B cells	53
Chapter 4 The DNA damage response regulates RAG1/2 expression in pre-B cells through ATM-FOXO1 signaling	81
Chapter 5 NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity	115
Chapter 6 DNA damage-induced p53 downregulates expression of RAG1 though a negative feedback loop involving miR-34a and FOXP1	147
Chapter 7 General discussion	167
Appendix	193
English summary	194
Nederlandse samenvatting	197
Zhrnutie v slovenčine	201
Authors’ contributions & Research funding	204
PhD portfolio & Publications	208
About the author	211
Acknowledgements	212

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