146 Chapter 8 Symptom severity at baseline and SES Data was complete for both VISA-A and baseline SES scores (Q1-Q5). Quintile 1 contained the largest proportion of AT patients (22.5%) and in all quintiles a larger proportion was male (Table 2). Table 2 shows the participant characteristics per quintile, which did not demonstrate statistically significant differences between the quintiles. VISA-A scores at baseline were similar for Q1 and Q5 (43.9 and 41.8, p=0.59. See Table 3). Table 2. Participants’ characteristics of the patients in each quintile. Data are presented as No. (%) unless otherwise specified. Abbreviations: BMI: Body Mass Index, AAS: Ankle Activity Score, SES: socioeconomic status Number of patients Sex (M/F) Age, median [IQR], (years) AAS score, median [IQR] BMI (kg/m2), median [IQR] Symptom duration , median [IQR] (weeks) Quintile 1 (highest SES score) 45 (22.5) 28 (62) / 17 (38) 50.0 [43.5-56.5] 4.0 [4.0-5.5] 25.5 [24.0-27.7] 126 [60-356] Quintile 2 37 (18.5) 20 (54) / 17 (46) 53.0 [49.0-59.5] 4.0 [4.0-5.0] 25.4 [23.0-28.9] 77 [43-206] Quintile 3 38 (19.0) 26 (68) / 12 (32) 45.5 [35.8-53.3] 5.0 [4.0-8.0] 25.2 [23.6-29.3] 104 [33-299] Quintile 4 41 (20.5) 24 (59) / 17 (41) 51.0 [34.5-56.0] 5.0 [4.0-8.0] 25.4 [22.8-28.1] 66 [37-154] Quintile 5 (lowest SES score) 39 (19.5) 23 (59) / 16 (41) 52.0 [32.0-59.0] 5.0 [4.0-7.0] 26.0 [23.8-30.0] 68 [27-208] Baseline SES and change in symptom severity during 24 weeks treatment The effect of baseline SES scores on change in symptom severity (measured with VISA-A and patient satisfaction) is depicted in Table 3 and 4 (complete case analysis). At baseline, 6-weeks and 12-weeks there were no statistically significant differences in VISA-A score between Q1 and Q5. At 24-weeks, there was a mean (95% Confidence Interval; CI) difference of 11.2 (1.0-21.3, p = 0.03) points on the VISA-A score in favor of Q1 (Table 3 and Figure 1). Supplementary File 1 shows the dispersion of the VISA-A scores for the overall population and the individual and mean VISA-A scores over time for Q1 and Q5.
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