Koert Gooijer

101 Chapter 5 were relatively common, 91% (n =177) of the patients had undergone surgery and 86,2% (n =168) had experienced a dental extractions. Of all 124 women, 91,9% (n =114) ever had a menstrual period and 42,7% (n =53) had been pregnant. Women with OI type 3 had never been pregnant. Of the women who had been pregnant, 47 had at least 1 delivery. The reason why 6 of the pregnant women did not give birth was not known. Three patients were known with von Willebrand disease (VWD). No other bleeding disorders were reported. Table 1 General descriptive data study population OI type 1 n =144 OI type 3 n =17 OI type 4 n =34 Sex, n (%) Male 49 (25) 7 (4) 15 (8) Female 95 (49) 10 (5) 19 (10) Age in years, mean (SD) 44.7 (15.2) 31.7 (13.1) 45.4 (16.3) Bleeding assessment Self-BAT score Self-BAT scores were above the normal range in 42% of all patients. For males Self-BAT scores were increased in 37% (n = 26) with a mean score of 3.7, ranged between 0;18. For females the Self-BAT scores were increased in 44% (n = 55) with a mean of 5.4 and a range of 0;24. There was no statistically significant difference between the OI types regarding severity of each bleeding symptom or total Self-BAT scores (Figure 1). The correlation between age and Self-BAT score is negligible (R² = 0,012). Figure 1 Correlation between Self-BAT bleeding score and OI types. Black lines are medians. Dashed line is cut-off score for men and women 20129630Self-BAT 1 3 4 OI type (woman) 18129630Self-BAT 1 3 4 OI type (men)

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