38 Vitality Only patients with OI type 1 showed a significantly lower vitality compared with the control group 5,11 (Table 1), except when >55 years 11 (Supplementary Table S2). Patients with OI types 3 and 4 did not have significantly reduced vitality compared with controls 11, except for OI type 3 in the age category of 35 to 54 years. There was no significant difference in vitality between the OI types in different age categories. Vitality in the control group 11 slightly decreased from the youngest to the eldest age group (Δ−4.5). This was similar in the patients with OI type 1 (Δ−0.1) and OI type 4 (Δ−8.83; Supplementary Table S1). Social functioning Social function in patients with OI with types 1, 3, and 4 was significantly lower compared with the control group 5,11 (Table 1). However, when analyzed per age category these results were in some instances not significant 11 (Supplementary Table S2). There was one statistically significant difference in social functioning between OI types in different age categories. In age category 18 to 25 years; people with OI type 3 scored significantly lower than people with OI type 1 and OI type 4. Role limitations caused by personal or emotional problems Role limitations caused by personal of emotional problems of patients with OI in general were not statistically different from the control population 5,11. Regarding the different age categories, there was a statistically significant difference between patients with OI type 4 and controls in the age category 18 to 24 years 11. There was no significant difference regarding role limitations between the OI types in all age categories. Individuals with OI type 4 scored lowest regarding role limitations in the age category 25 to 34 years (Supplementary Table S1). Patients with OI type 4, aged 19 to 24 years, scored highest, even significantly higher than the control group 11. Mental health We observed—only in patients with OI type 1—a very small, but significantly reduced mental health compared with controls 5,11 (Table 1). When analyzing specific age categories in patients with OI type 1, patients with OI aged 35 to 54 years had a significant reduced mental health (Supplementary Tables S1 and S2). There was no significant difference between the OI types. The oldest and the youngest groups had similar outcomes.
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