42 Conclusion Our study described baseline QoL measurements in the largest group of adults with different types of OI to date (n = 322) and compared outcomes with (age-matched) control groups. The mean scores indicated that people with OI generally had a significantly lower QoL than the control population, and the scores per domain gave insight into which domains at what age in which OI type were more severely affected. This is important information for aging patients with OI and their health care professionals. Longitudinal QoL measurement and further qualitative evaluation of QoL and its influences are important for future management and improvement of QoL in people with OI.
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