Koert Gooijer

48 18-24 OI 1 OI 3 OI 4 OI 1 x x x OI 3 0.000 x x OI 4 0.013 0.036 x Control 0.000 0.000 0.000 35-54 OI 1 OI 3 OI 4 OI 1 x x x OI 3 0.017 x x OI 4 1.000 0.135 x Control 0.000 0.000 0.001 25-34 OI 1 OI 3 OI 4 OI 1 x x x OI 3 0.000 x x OI 4 0.830 0.000 x Control 0.000 0.000 0.000 55+ OI 1 OI 3 OI 4 OI 1 x x x OI 3 0.064 x x OI 4 0.574 0.018 x Control 0.022 0.003 0.827 Trend Difference P-value OI 1 -21.72 0.000 OI 3 2.5 1.000 OI 4 18.65 0.563 Control -27.85 0 Figure 1a appendix visualisation of table 1 appendix Physical functioning Table 2a Appendix Significance (p- value) of differences between OI types and controls (data shown in Table 1 Appendix) Underlined = Not-normally distributed

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