Koert Gooijer

52 18-24 OI 1 OI 3 OI 4 OI 1 x x x OI 3 0.000 x x OI 4 0.048 0.163 x Control 0.003 0.000 0.000 35-54 OI 1 OI 3 OI 4 OI 1 x x x OI 3 0.289 x x OI 4 1.000 0.294 x Control 0.000 0.000 0.000 25-34 OI 1 OI 3 OI 4 OI 1 x x x OI 3 0.068 x x OI 4 1.000 0.073 x Control 0.000 0.000 0.000 55+ OI 1 OI 3 OI 4 OI 1 x x x OI 3 1.000 x x OI 4 0.226 0.874 x Control 0.000 0.016 0.028 Trend Difference P-value OI 1 -8.01 0.003 OI 3 5.72 1.000 OI 4 5.96 0.852 Control 0 1 Figure 1e appendix visualisation of table 1 appendix Physical component summary score Table 2e Appendix Significance (p- value) of differences between OI types and controls (data shown in Table 1 Appendix) Underlined = Not-normally distributed

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