88 Fibrinolysis The ROTEM test was performed to determine fibrinolysis in all 22 included OI patients (Table 1). One patient (Patient 5) had 17% fibrinolysis of (reference range <15%) (Figure 3); this patient had OI type 3 due to a c.2461G>A p.(Gly821Ser) pathogenic COL1A1 variant. He had no other abnormal laboratory test results and a BS of 0. Another patient (Patient 6) had 15% fibrinolysis, OI type 1 due to a c.859-1G>A pathogenic COL1A1, a BS of 0 and no other abnormalities. Figure 3 ROTEM trace with increased fibrinolysis α: alpha angle; A5: amplitude at 5 min; A10: amplitude at 10 min; CFT, clot formation time; CT, clotting time; EXTEM, screening test for the extrinsic haemostasis system; INTEM, screening test for the haemostasis system; MCF, maximum clot firmness; ML, maximum lysis
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