2 Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction 23 Figure 2. Morphology and cystine measurements. (a) Morphology of wild-type and ctns‒/‒ larvae at 4 dpf. Wild-type larva shows normal morphology, while mutant ctns‒/‒ larvae show various degrees of developmental delay and deformity: upper larva show signs of growth retardation in the form of slightly bigger yolk, bulging heart and bent-down head, while the middle and lower larvae show mild and severe deformity, respectively
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