Table of Contents Chapter 1. General introduction and outline 7 Chapter 2. Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction 17 Chapter 3. Glomerular permeability is not affected by heparan sulfate glycosaminoglycan deficiency in zebrafish embryos 47 Chapter 4. Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier 65 Chapter 5. Increased dynamin expression precedes proteinuria in glomerular disease 83 Chapter 6. Transmembrane Protein 14A protects glomerular filtration barrier integrity 103 Chapter 7. General discussion and future perspectives 121 Appendices Nederlandse samenvatting 138 Curriculum vitae 144 List of publications 145 Dankwoord 146
RkJQdWJsaXNoZXIy MTk4NDMw