4 Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier 73 Figure 3. Light microscopy of glomeruli from MO patients shows relatively normal morphology Snapshots of glomeruli from MO patients are shown. No specific lesions other than those related to the primary disease were observed. The examples are derived from patients with IgA nephropathy (A, PAS), glomerulonephritis after transplantation (B, H&E), and neoplastic diseases (C, H&E and D, PASD). Original magnification 40x. Scale bar = 50 µm Evaluation of the renal sections by light microscopy did not reveal notable changes that could be specific for MO (56). A selection of representative images is shown in figure 3. However, EM analysis revealed a highly aberrant phenotype in one case with a noteworthy clinical history. This patient had received a kidney transplantation after suffering from a renal insufficiency. The primary disease was noted to have ‘membrane anomalies reminiscent of a hereditary nephritis. We re-examined the EM grids of this patient, and found segmental fibrillar deposition that seemed similar to that reported by Roberts et al.
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