5 Increased dynamin expression precedes proteinuria in glomerular disease 89 Table 1. Differential glomerular expression of cytoskeleton-related genes between 4-6-week-old Dahl rats and SHR rats Gene name Gene symbol Chromosomal location Fold difference in expression Function periplakin Ppl 10q12 4.17 intermediate filament binding moesin Msn Xq31 3.86 actin filament -- membrane cross-linking dynamin 1 Dnm1 3p11 3.36 actin dynamics regulation tropomyosin 4 Tpm4 16p14 2.73 actin binding thymoma viral proto-oncogene 1 Akt1 6q32 2.71 cell projection organization and biogenesis supervillin Svil 17q12 2.62 actin binding parvin, alpha Parva 1q33 2.62 actin cytoskeleton organization and biogenesis plastin 3 (T-isoform) Pls3 Xq14 2.51 actin filament organization tropomyosin 1, alpha Tpm1 8q24 2.23 actin filament capping microtubule-associated protein, RP/EB family, member 1 Mapre1 3q41 2.2 regulation of microtubule polymerization Rho guanine nucleotide exchange factor (GEF) 17 Arhgef17 1q32 2.1 actin cytoskeleton organization and biogenesis caldesmon 1 Cald1 4q22 2.1 actin binding signal-regulatory protein alpha Sirpa 3q36 2.04 actin filament organization WD repeat domain 44 Wdr44 Xq12 2 vesicle recycling myosin Ib Myo1b 9q22 1.99 actin binding echinoderm microtubuleassociated protein like 4 Eml4 6q12 1.97 microtubule stabilization actin-related protein 2/3 complex, subunit 1B Arpc1b 12p11 1.89 cytoskeleton organization filamin, beta Flnb 15p14 1.87 actin binding myosin IC Myo1c 10q24 1.78 actin binding mitogen-activated protein kinase 1 Map3k1 2q14 1.78 actin filament polymerization CAP, adenylate cyclaseassociated protein 1 (yeast) Cap1 5q36 1.73 actin cytoskeleton organization and biogenesis kinesin light chain 1 Klc1 6q32 1.59 microtubule motor activity Src homology 2 domaincontaining transforming protein C1 Shc1 2q34 1.57 actin cytoskeleton organization and biogenesis ARP1 actin-related protein 1 homolog A (yeast) Actr1a 1q54 1.55 cytoskeleton organization actin, beta Actb 12p11 1.54 cytoskeleton organization A kinase (PRKA) anchor protein 2 Akap2 5q24 1.51 actin filament organization spectrin alpha 1 Spna1 13q24 0.19 cytoskeleton organization polyamine modulated factor 1 binding protein 1 Pmfbp1 19q12 0.14 cytoskeleton organization and biogenesis
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