List of Tables 2.1 S-ketamine PK - Subject characteristics . . . . . . . . . . . . . . 20 2.2 S-ketamine PK - Pharmacokinetic parameters OTF . . . . . . . 23 2.3 S-ketaminePK-Adverseeffects . . . . . . . . . . . . . . . . . . 24 2.4 S-ketamine PK - OTF pharmacokinetics . . . . . . . . . . . . . . 27 3.1 S-ketamine PD - Pharmacodynamic parameter estimates . . . . 51 4.1 Oliceridine respiratory effects - PK parameter estimates . . . . . 79 4.2 Oliceridine respiratory effects - PD parameter estimates . . . . . 83 4.3 Oliceridine respiratory effects - Adverse effects . . . . . . . . . . 86 5.1 CB Hypoxia - Subject characteristics . . . . . . . . . . . . . . . . 106
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