1 Introduction Study objectives The objectives of this thesis are: 1. To quantify the pharmacokinetics and pharmacodynamics (pain relief and psychomimetic adverse effects) of a novel S-ketamine oral thin film; 2. To quantify the pharmacokinetics and respiratory pharmacodynamics of the biased ligand oliceridine, in comparison to morphine; 3. Explore the effects of insulin on the hypoxic ventilatory response in type 2 diabetics compared to healthy controls. 7
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