The investigations described in chapters 2-5 of this thesis were performed in the Anesthesia & Pain Research Unit, Leiden University Medical Center, under the supervision of prof. dr. A. Dahan and dr. R. van der Schrier. Copyright ©2024 Pieter Simons. ISBN 978-94-6506-095-8 No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without prior permission of the author. Typeset by LATEX Cover design by Anneriek Simons Printed by Ridderprint, the Netherlands The printing of this thesis was financially supported by: ChipSoft and Trevena.
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