Figure 2.1: Mean measured plasma concentrations following application of the 50 and 100 mg S-ketamine oral thin film (OTF): (A) S-ketamine, (B) S-norketamine and (C) S-hydroxynorketamine. Individual concentrations are given in panels D-F for the 50 mg oral thin film, and G-I for the 100 mg oral thin film. In black the results of placement below the tongue, in red buccal placement. The OTF was administered at t = 0 min for 10 min (green bars); at t = 360 min, an intravenous dose of 20 mg S-ketamine was administered over 20 min (light orange bars). 22
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