Figure 2.2: Final pharmacokinetic model. K = S-ketamine, N = S-norketamine and H=S-hydroxynorketamine. KA1 and KA2 are S-ketamine rate constants. G.I. tract = gastrointestinal tract. Cp = plasma concentration. K1, N1 and H1 are the central compartments for S-ketamine, S-norketamine and S-hydroxynorketamine, respectively. VN1 and VK1 are the volumes of the central compartments of S-ketamine and S-norketamine, respectively. Kx, Nx and Hx are the peripheral compartments for S-ketamine, S-norketamine and S-hydroxynorketamine, respectively, with x = compartment 2 or 3. CL = clearance with CLK1 and CLN1 S-ketamine and S-norketamine clearances from the central compartment towards the metabolism compartment, respectively and CLK2, CLK3, CLN2 and CLH2 intercompartmental clearances. CLH1 is the terminal S-hydroxynorketamine clearance. MTT = mean transit (or delay) time with MTTG the mean transit time from the gut to the liver. 26
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