Table 2.4 continued from previous page Parameter Estimate SEE Inter-subject variability (ω2) SEE Inter-occasion variability (ν2) SEE S-norketamine Volume of S-norketamine compartment 1; VN1 11.6 0.9 0.057 0.019 11.6 Volume of S-norketamine compartment 2; VN2 (L @ 70 kg) 221 13 Clearance of S-norketamine compartment 1; CLN1 (L/min @ 70 kg) 1.00 0.04 0.050 0.012 Clearance of S-norketamine compartment 2; CLN2 (L/min @ 70 kg) 2.63 0.15 Mean transit time K®NK (min) 20.1 1.0 0.021 0.122 Outlier mean transit time (id = 4) (min) 8.72 0.19 sRelative (relative within-subject variability) 0.102 0.007 sAdditive (additive within-subject variability) 0.058 0.018 0.751 0.349 S-hydroxynorketamine Volume of S-hydroxynorketamine compartment 1; VH1 (L @ 70 kg) 4.4 2.0 1.22 0.91 Volume of S-hydroxynorketamine compartment 2; VH2 (L @ 70 kg) 87.5 6.5 0.152 0.031 Clearance of S-hydroxynorketamine compartment 1; CLH1 (L/min @ 70 kg) 0.933 0.068 0.103 0.042 0.008 0.004 Clearance of S-hydroxynorketamine compartment 2; CLH2 (L/min @ 70 kg) 1.70 0.25 0.287 0.124 28
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