2 S-ketamine oral thin film pharmacokinetics Figure 2.4: Simulations showing the effect of changing the duration of placement of the 50 mg oral thin file in the mouth by changing both F1 (bioavailability) and D (duration of absorption) on the plasma concentrations of S-ketamine (A), Snorketamine (B) andS-hydroxynorketamine (C). F is a factor by which D1 is adjusted and ranges from 0.5 (red lines) to 1 (blue lines) and 2 (green lines). 31
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