2 S-ketamine oral thin film pharmacokinetics In conclusion, the S-ketamine oral thin film is a safe and practical alternative to intravenous S-ketamine administration that results in relatively high concentrations of S-ketamine and its two metabolites. Figure 2.5: Simulation showing the S-ketamine (continuous green line) and Shydroxynorketamine (broken green line) concentration profiles following a 0.5 mg/kg S-ketamine infusion, given for 40 min in a 70-kg individual. As comparator the equivalent concentrations are given following the 100 mg S-ketamine oral thin film (blue continuous =S-ketamine, and broken blue line =S-hydroxynorketamine). 35
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