3 S-ketamine oral thin film pharmacodynamics Figure 3.1: Pharmacokinetic data. Average plasma concentrations ± 95% confidence intervals for S-ketamine, S-norketamine and S-hydroxynorketamine following administration of 50 mg (A) and 100 mg (B) S-ketamine oral thin film. Figure 3.2: Antinociceptive data. The effects of the 50 mg and 100 mg S-ketamine oral thin film on pain responses for the three pain assays, pressure pain threshold (A), electrical pain numerical rating scale (B), and heat pain numerical rating scale (C). Data are mean ±95% confidence interval. 49
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