3 S-ketamine oral thin film pharmacodynamics Table 3.1: Pharmacodynamic parameter estimates Estimate ±SEE ω2 ±SEE ν2 ±SEE Electrical pain NRS (0-10) Baseline NRS 7.2 ±0.2 0.025 ±0.010 t1/2ke0 (min) 3.4 ±0.4 1.13 ±0.81 C50 (nmol/mL) 1.3 ±0.2 1.01 ±0.32 γ 1 (FIX) σ 0.75 ±0.07 Heat pain NRS (0 -10) Baseline NRS 7.9 ±0.2 0.011 ±0.006 t1/2ke0 (min) - C50 (nmol/mL) 1.2 ±0.32 0.57 ±0.27 γ 1 (FIX) 0.57 ±0.31 σ 0.66 ±0.08 Pressure pain Baseline (N) 56 ±5 0.09 ±0.03 0.03 ±0.01 t1/2ke0 (min) - C50 (nmol/mL) 1.7 ±0.29 0.27 ±0.11 γ 1 (FIX) σ (N) 9.26 ±1.18 Drug high VAS (0-10 cm) t1/2ke0 (min) 5.4 ±0.2 1.1 ±0.69 C50 (nmol/mL) 0.31 ±0.03 0.16 ±0.08 γ 2.8 ±0.3 0.15 ±0.05 σ 0.89 ±0.10 NRS = numerical rating scale; t1/2ke0 is blood-effect-site equilibration halflife; C50 is the concentration at steady-state causing 50% effect; γ is a shape parameter and σ a measure of residual noise. 51
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