Figure 3.5: Visual predictive checks of the pharmacodynamic model in for the two S-ketamine OTF doses. The circles are the measured data points; the broken lines are the observed percentiles (dark red: median, dark blue: 2.5th and 97.5th percentiles); the bins are the 95% confidence intervals of simulated percentiles (orange bins: median, blue bins: 2.5th and 97.5th percentiles). A. Pain threshold; B. Electrical pain numerical rating scale (NRS); C. Heat pain NRS; D. Drug high visual analog scale (VAS). 54
RkJQdWJsaXNoZXIy MTk4NDMw