Contents 1 Introduction 1 2 S-ketamine oral thin film pharmacokinetics 13 3 S-ketamine oral thin film pharmacodynamics 41 4 Oliceridine respiratory effects 65 5 Diabetes, hyperinsulinemia, and the hypoxic ventilatory response 99 6 Summary, conclusions, and perspectives 121 7 Nederlandse samenvatting 131 Addenda 135
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