Pieter Simons

Figure 4.1: ˙V E55 change from baseline (%) after dosing. Ventilation at an extrapolated carbon dioxide partial pressure of 55 mmHg, ˙VE55, during a hypercapnic ventilatory response, for the four treatment arms (green oliceridine 0.5 mg, blue oliceridine 2 mg, orange morphine 2 mg and red morphine 8 mg). Data are averaged percentage of baseline ±95% confidence interval. 74

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