4 Oliceridine respiratory effects Figure 4.3: Goodness-of-Fit PK data. Goodness-of-Fit plots of the pharmacokinetic data analyses for morphine (panels A-D) and oliceridine (panels E-H). Aand E. Measured concentration versus individual predicted concentration. Band F. Measured concentration versus population predicted concentration. Cand G. Conditional weighted residuals versus time. D and H. Normalized prediction discrepancy error versus time. The dotted lines represent the upper and lower limits of the 95% confidence interval. Red symbols morphine 2 mg, green symbols morphine 8 mg, blue symbols oliceridine 0.5 mg, yellow symbols oliceridine 2 mg. 77
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