Figure 4.4: Population pharmacokinetic model. The population pharmacokinetic model outcome (red lines) and the observed pharmacokinetic data points of each individual versus time for morphine 2 mg (A), morphine 8 mg (B), oliceridine 0.5 mg (C) and oliceridine 2 mg (D). For oliceridine the status of the CYP2D6 genotype is given: poor metabolizer (green), intermediate metabolizer (dark yellow), normal metabolizer (blue) and ultra-rapid metabolizer (yellow). 78
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