4 Oliceridine respiratory effects Figure 4.5: Population pharmacodynamic model outcome.The population pharmacodynamic model outcome (red lines) and the measured pharmacodynamic data points ( ˙VE55) of each individual versus time for morphine 2 mg (A), morphine 8 mg (B), oliceridine 0.5 mg (C) and oliceridine 2 mg (D). Data are averaged percentage of baseline ±95% confidence interval. 81
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