Table 4.3: Adverse effects Oliceridine Morphine 0.5mg 2mg 2mg 8mg Apnea* 1 Bradycardia 1 3 Dizziness 4 12 4 7 Drowsiness 1 1 1 2 Flushing 3 1 2 Headache 3 6 4 4 Hoarseness 1 Lightheadedness 5 8 3 8 Myalgia shoulders 1 Nausea (without vomiting) 6 2 10 Nausea and vomiting 1 2 5 Numbness shoulders 1 Paresthesia extremities 1 1 3 Paresthesia whole body 1 Pruritis at injection site 1 2 1 Rigidity of the thorax 1 Shivering 1 Slurred speech 2 1 Somnolence 4 7 2 6 Syncope 1 1 1 Vertigo (horizontal) 2 6 3 Vertigo (vertical) 4 2 Total 20 59 26 62 Data are n (subjects); *cessation of breathing for at least 30 s. 86
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