Pieter Simons

1 Introduction	13
2 S -ketamine oral thin film pharmacokinetics	25
3 S -ketamine oral thin film pharmacodynamics	53
4 Oliceridine respiratory effects	77
5 Diabetes, hyperinsulinemia, and the hypoxic ventilatory response	111
6 Summary, conclusions, and perspectives	133
7 Nederlandse samenvatting	143
Addenda	147

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