134 Chapter 5 Relevance and synthesis of the results Compared with the Dutch general population, the study population reported slightly lower scores on the CAT physical function, which indicates that the study population experiences more limitations in their physical functioning then the Dutch general population (Table 5). Of the Dutch general population, 32% reported to have mild, moderate or severe limitations in their physical functioning, while 45% of the study population reported to experience limitations in their physical functioning 38. On all other PROMIS CATs, the study population reported similar or less symptoms/limitations compared to the general population. Table 2: Number of completed items, floor and ceiling effects, and reliability of the PROMIS measures in adults with von Willebrand disease. No. of items Floor Ceiling Reliability PROMIS measure N Mean SD Min Max % % Coefficient CATs Physical function 67 6.2 2.8 4 12 0% 0% 0.96 Pain interference 67 7.5 3.8 4 12 39% 2% 0.91 Fatigue 66 6.1 2.8 4 12 3% 0% 0.96 Anxiety 66 8.7 2.4 5 12 3% 0% 0.94 Depression 65 7.2 1.7 4 9 15% 0% 0.93 Ability to participate in social roles and activities 64 6.4 2.9 4 12 0% 11% 0.95 Satisfaction with social roles and activities 64 5.3 2.5 4 12 0% 8% 0.96 Short Form Anger 63 5 - 5 5 14% 0% 0.90 Fixed scale Global Health – physical health 62 4 - 4 4 0% 0% 0.82 Global Health – mental health 62 4 - 4 4 13% 0% 0.82 Abbreviations: CATs, Computer Adaptive Tests; Max, maximum; Min, minimum; No, number; PROMIS, Patient Reported Outcomes Measurement Information System; SD, standard deviation.
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