135 PROMIS in VWD, IPFDs and RBDs 5 In summary, the mean number of items needed to complete on the selected PROMIS CATs was larger than the SF-36v2. Floor effects were present on two PROMIS CATs, while ceiling effects were present on five domains of the SF36v2. The PROMIS CATs anxiety and depression had a good construct validity. The other PROMIS CATs had excellent construct validity. All PROMIS measures and the SF-36v2 domains had a good group-level reliability and the PROMIS CATs, short form anger and the SF-36v2 domains physical functioning, role limitation due to physical health problems, role limitations due to emotional problems, mental health, bodily pain, and general health displayed a good reliability on individual level. Compared to the general population, the relevance of the selected PROMIS CATs was limited (Table 6). Table 3: Number of completed items, floor and ceiling effects, and reliability of the SF-36v2 in adults with von Willebrand disease. Floor Ceiling Reliability Instruments N No. of items % % Cronbach’s α Greatest lower bound SF-36v2 Physical functioning 63 10 6% 21% 0.94 0.98 Role limitations due to physical health problems 63 4 5% 86% 0.88 0.93 Role limitations due to emotional problems 63 3 5% 94% 0.96 0.96 Vitality 63 4 0% 0% 0.82 0.89 Mental health 63 5 0% 0% 0.85 0.92 Social functioning 63 2 2% 40% 0.80 0.80 Bodily pain 63 2 0% 32% 0.91 0.91 General health 63 5 2% 5% 0.87 0.91 Physical component score 63 21 0% 0% 0.83 0.86 Mental component score 63 14 0% 0% 0.77 0.85 Abbreviations: No, number; SF-36v2, Short Form-36 version 2.
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