142 Chapter 5 Essentials • This study investigates Patient Reported Outcomes Measurement Information System (PROMIS). • In this multicenter study, 111 adults with autosomal inherited bleeding disorders participated. • All analyzed PROMIS measures are reliable and valid alternatives for the Short Form-36 version 2. • All studied PROMIS Computer Adaptive Tests can be used in clinical practice. Keywords Von Willebrand diseases; Blood platelet disorders; Coagulation protein disorders; Patient reported outcome measures; Adult; Feasibility studies. Author contributions E.S. van Hoorn, M.H. Cnossen, S.C. Gouw and H.F. Lingsma conceived the study. S.P.E Willems, C.B. van Kwawegen, I.C.L. Kremer Hovinga, R.E.G. Schutgens, S.E.M. Schols, F.W.G. Leebeek, L. Haverman contributed to study design. Data collection was led by E.S. van Hoorn and supported by S.P.E. Willems, W. Al Arashi, A.S. de Moor, C.B. van Kwawegen and L. Teela. E.S. van Hoorn performed the statistical analysis and S.P.E. Willems, L. Teela, M.A.H. Oude Voshaar and L. Haverman contributed to the interpretation of the data and modification of statistical analysis. The first draft of the manuscript was written by E.S. van Hoorn. M.A.H. Oude Voshaar, M.H. Cnossen, S.C. Gouw and H.F. Lingsma were responsible for the supervision. All authors critically revised the manuscript for intellectual content and approved the final version of the manuscript. Conflicts of interest R.E.G. Schutgens has received unrestricted research and speaker fees from Novartis, NovoNordisk, Sanofi, Sobi and Octapharma. S.E.M. Schols has received travel grants from Takeda and Bayer, an unrestricted educational grant from Takeda and has served as a steering board member for Roche and Novo Nordisk. F.W.G. Leebeek has received unrestricted research grants from CSL Behring, Takeda, Sobi and uniQure. He is a consultant for CSL Behring, Takeda, Biomarin and uniQure, of which the fees go to the University. L. Haverman is a member of the Dutch-Flemisch PROMIS group. M.H. Cnossen has received grants from governmental and societal research institutes e.g. NWO-ZonMW, NWO-NWA, Innovation fund, and unrestricted investigator initiated research grants from private funds, as well as institutional grants, trial
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