42 Chapter 2 Author, (year), country Study design and characteristics of population (n; gender; disease type; age) PROMs Measured PROs PROs and conclusions* Huq, F. Y., et al. (2012). UK 30 Retrospective, single center 12 patients with different inherited bleeding disorders (all female) and HMB • VWD: 3 • VWD & HA carrier: 2 • IPFD: 2 • FXI def.: 2 • FX def.: 1 • HA carrier: 2 Age (years) • mean: 44.3 • range: 34-51 Ad hoc questionnaire • HRQoL • General health • Physical activity • Dysmenorrhea • After treatment HRQoL scores improve (p<0.0001), especially scores on general health and health and daily activity (p<0.01). • Before treatment 58% of patients reported moderate to severe dysmenorrhea and after treatment 16.6% patients had dysmenorrhea (p<0.01). • Before treatment more than half of patients reported moderately or more interference of dysmenorrhoea with daily work and after treatment 8,3% of patients reported moderately or more interference of dysmenorrhoea with daily work (p<0.01).
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