44 Chapter 2 Author, (year), country Study design and characteristics of population (n; gender; disease type; age) PROMs Measured PROs PROs and conclusions* Kirtava, A., et al. (2003). USA 34 Prospective, multicenter 102 patients with VWD (all female) Age (years; SD) • mean: 39 (11.9) • range: 18-70 Control group: Individuals without VWD (n=88) Ad hoc questionnaire CES-D • Daily activities and lifestyle • Depression • Health perception • Patients have similar prevalence of depression compared to controls (p>0.2). • Patients were more negatively affected in activity (routine work and social activities) and lifestyle by their menstruation compared to controls (p=0.004). • Patient more often reported negative perception of health (fair or poor) compared to controls (p=0.004). Kouides, P. A., et al. (2000). USA 35 Prospective, multicenter 81 patients with VWD (all female) • Type 1: 81 Age (years; SD) • mean: 31.0 (10.7) • range: 11-49 Control group: women with menstrual cycles and no VWD (n=150) Ad hoc questionnaire • HRQoL • Psychosocial functioning • Patients were more negatively affected by their menstruation compared to controls in the domains general activity, ability to work or go to school, family activities, ability to enjoy life, sleep, mood and overall HRQoL (p<0.001). • Approximately half (46%) of patients report losing time from work or school due to HMB.
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