104 Chapter 5 S.5.8.4. Secondary analyses of WMH volumes per lobe and long-term dementia risk. No dementia at follow-up (mean ± SD) Dementia at follow-up (mean ± SD) Model 1 HR (95% CI) Frontal lobe Deep volume (ml) 0.87 ± 1.03 1.13 ± 1.02 1.25 (1.14–1.36)*** PV/C volume (ml) 5.11 ± 6.73 10.27 ± 11.01 1.58 (1.45–1.73)*** Parietal lobe Deep volume (ml) 0.22 ± 0.30 0.29 ± 0.32 1.21 (1.12–1.31)*** PV/C volume (ml) 3.22 ± 4.26 6.23 ± 6.36 1.56 (1.41–1.73)*** Occipital lobe Deep volume (ml) 0.26 ± 0.39 0.16 ± 0.33 0.90 (0.83–0.98)* PV/C volume (ml) 1.87 ± 1.75 3.04 ± 2.23 1.73 (1.51–1.98)*** Temporal lobe Deep volume (ml) 0.05 ± 0.09 0.07 ± 0.13 1.03 (0.96–1.11) PV/C volume (ml) 2.72 ± 2.29 4.09 ± 2.80 1.51 (1.36–1.68)*** A hazard ratio below 1 means that higher values decrease the risk of developing dementia. A hazard ratio above 1 means that higher values increase the risk of developing dementia. As WMH volumes increase, confluent WMH can merge with deep WMH. This will in turn lower the deep WMH volumes and may explain why lower deep WMH volumes were found in the occipital lobe in participants who developed dementia at follow-up. Model 1: controlled for age, sex, cognitive status at baseline and intracranial volume. * p<0.05; ** p<0.01; ***p<0.001.
RkJQdWJsaXNoZXIy MTk4NDMw