106 Chapter 5 S.5.8.6. Sensitivity analyses excluding over-segmentation. Mean ± SD of WMH shape markers and WMH volumes including the model 1 cox regression. No dementia at follow-up (mean ± SD) n=2330 Dementia at follow-up (mean ± SD) n=685 Hazard ratio (95% CI) Periventricular/confluent WMH shape Solidity 0.20 ± 0.12 0.16 ± 0.07 1.32 (1.16–1.51) *** Convexity 1.03 ± 0.17 0.93 ± 0.19 1.38 (1.28–1.50) *** Concavity Index 1.27 ± 0.15 1.37 ± 0.16 1.44 (1.33–1.56) *** Fractal dimension 1.70 ± 0.16 1.79 ± 0.31 1.43 (1.31–1.57) *** Deep WMH shape Eccentricity 0.39 ± 0.08 0.39 ± 0.06 0.98 (0.90–1.06) Fractal dimension 1.70 ± 0.14 1.69 ± 0.12 1.04 (0.96–1.13) WMH Volumes Total WMH volume 16.64 ± 14.96 28.38 ± 21.45 1.69 (1.53–1.86) *** Periventricular/confluent WMH volume 15.18 ± 14.60 26.66 ± 21.23 1.72 (1.55–1.90) *** Deep WMH volume 1.46 ± 1.35 1.71 ± 1.32 1.16 (1.07–1.26) ** The cox-regression results were not affected by participants with mild/moderate over-segmentation (n=62). In order to test this the participants with mild/moderate over-segmentation were excluded and model 1 (adjusted for age, sex, and cognitive status at baseline) was run on the remaining participants. WMH volumes were additionally controlled for intracranial volume. A hazard ratio below 1 means that higher values decrease the risk of developing dementia. A hazard ratio above 1 means that higher values increase the risk of developing dementia. **p<0.01 ***p<0.001
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