107 White matter hyperintensity shape is associated with long-term dementia risk 5 S.5.8.7. Sensitivity analyses excluding participants with subcortical infarcts/lacunes. Mean ± SD of WMH shape markers and WMH volumes including the model 1 cox regression. No dementia at follow-up (mean ± SD) n=2186 Dementia at follow-up (mean ± SD) n=625 Hazard ratio (95% CI) Periventricular/ Confluent WMH shape Solidity 0.20 ± 0.12 0.16 ± 0.07 1.34 (1.17–1.53) *** Convexity 1.04 ± 0.17 0.94 ± 0.19 1.40 (1.30–1.53) *** Concavity Index 1.26 ± 0.15 1.36 ± 0.16 1.46 (1.34–1.58) *** Fractal dimension 1.70 ± 0.16 1.78 ± 0.13 1.42 (1.29–1.56) *** Deep WMH shape Eccentricity 0.39 ± 0.08 0.38 ± 0.07 1.00 (0.92–1.09) Fractal dimension 1.69 ± 0.14 1.69 ± 0.12 1.01 (0.93–1.10) WMH volumes Total WMH volume 16.14 ± 14.54 26.62 ± 19.46 1.66 (1.49–1.84) *** Periventricular/confluent WMH volume 14.69 ± 14.15 24.88 ± 19.14 1.68 (1.51–1.87) *** Deep WMH volume 1.46 ± 1.35 1.74 ± 1.36 1.18 (1.08–1.28) *** The cox-regression results were not affected by participants with subcortical infarcts/lacunes. 266 participants with subcortical infarcts/lacunes were excluded and model 1 (adjusted for age, sex, and cognitive status at baseline) was performed on the remaining participants. WMH volumes were additionally controlled for intracranial volume. A hazard ratio below 1 means that higher values decrease the risk of developing dementia. A hazard ratio above 1 means that higher values increase the risk of developing dementia. ***p<0.001
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