109 White matter hyperintensity shape is associated with long-term dementia risk 5 S.5.8.9. Sensitivity analyses to test the influence of neurodegenerative brain changes on model 1. Model 1 HR (95% CI) Periventricular/confluent WMH shape Solidity 1.38 (1.21–1.57*** Convexity (1.25–1.46)*** Concavity Index 1.41 (1.31–1.52)*** Fractal Dimension 1.41 (1.29–1.54)*** Deep WMH shape Eccentricity 0.98 (0.90–1.06) Fractal dimension 1.04 (0.96–1.13) WMH volumes Total WMH volume 1.60 (1.45–1.76)*** Periventricular/confluent WMH volume 1.63 (1.47–1.80)*** Deep WMH volume 1.14 (1.00–1.24)** These additional analyses were performed to test the influence of neurodegenerative brain changes on the found associations. For WMH shape a hazard ratio below 1 means that higher values decrease the risk of developing dementia. A hazard ratio above 1 means that higher values increase the risk of developing dementia. Model 1: controlled for age, sex, cognitive status at baseline, and hippocampal volumes (ml). For WMH volumes the analyses were additionally controlled for intracranial volume. **p<0.01 ***p<0.001
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