118 Chapter 6 6.3.5.3 Long-term outcome assessment A Cox proportional hazard model was used to estimate the risk of future dementia occurrence within the brain MRI phenotype subgroups (adjusted for age, sex, and cognitive status at baseline (mild cognitive impairment or normal cognition). The reference subgroup was chosen based on having the fewest brain abnormalities. SPSS version 25 was used for statistical testing. Table 6.1. Baseline characteristics of the total study sample. Community-dwelling individuals (n = 3056) Age (years) 75.6 ± 5.2 Time to follow-up (years) 9.9 ± 2.6 Female sex 1884 (62%) Mild cognitive impairment 257 (8%) BMI (kg/m2) 26.97 ± 4.19 Hypertension 2380 (78%) Type 2 diabetes 277 (9%) Cholesterol (mmol/L) 5.71 ± 1.14 Smoking status Never 1397 (46%) Former 1334 (44%) Current 324 (11%) Coronary artery disease 497 (16%) Data are shown as means ± SD or percentages of individuals per subgroup. BMI, body mass index; SD, standard deviation. 6.3.6 Data availability The AGES I-II data set cannot be made publicly available because the informed consent signed by the participants prohibits data sharing on an individual level, as outlined by the study approval by the Icelandic National Bioethics Committee. Requests for these data may be sent to the AGES Reykjavik Study Executive Committee, contact: Ms. Camilla Kritjansdottir, Camilla@hjarta.is.
RkJQdWJsaXNoZXIy MTk4NDMw