54 Chapter 3 Table S.3.9.2. In depth cerebrovascular MRI markers of the participants (n=2297). Baseline Follow-up Change over time WMH volume (ml) 16.56 ± 17.21 22.32 ± 22.18 5.76 ± 7.74 Participants with subcortical infarcts 153 (7%) 221 (10%) 68 (3%) with 1 subcortical infarct 118 [77%] 157 [71%] 39 [57%] with 2 subcortical infarcts 21 [14%] 33 [15%] 12 [18%] with 3 subcortical infarcts 5 [3%] 17 [8%] 12 [18%] with 4 subcortical infarcts 5 [3%] 7 [3%] 2 [3%] with ≥5 subcortical infarcts 4 [3%] 7 [3%] 3 [4%] Participants with microbleeds 381 (17%) 680 (30%) 299 (13%) with 1 microbleed 268 [70%] 434 [64%] 166 [56%] with 2 microbleeds 62 [16%] 119 [18%] 57 [19%] with 3 microbleeds 22 [6%] 46 [7%] 24 [8%] with 4 microbleeds 14 [4%] 27 [4%] 13 [4%] with ≥5 microbleeds 15 [4%] 54 [8%] 39 [13%] Participants with enlarged PVS 358 (16%) 397 (17%) 39 (2%) with 1 enlarged PVS 273 [76%] 296 [75%] 23 [59%] with 2 enlarged PVS 54 [15%] 62 [16%] 8 [21%] with 3 enlarged PVS 13 [4%] 20 [5%] 7 [18%] with 4 enlarged PVS 10 [3%] 7 [18%] -3 [8%] with ≥5 enlarged PVS 8 [2%] 12 [3%] 4 [10%] Participants with cerebellar infarcts 434 (19%) 596 (26%) 162 (7%) with 1 cerebellar infarct 279 [64%] 336 [56%] 57 [35%] with 2 cerebellar infarcts 91 [22%] 140 [23%] 43 [27%] with 3 cerebellar infarcts 19 [4%] 50 [8%] 31 [19%] with 4 cerebellar infarcts 14 [3%] 22 [4%] 8 [5%] with ≥5 cerebellar infarcts 25 [6%] 48 [8%] 23 [14%] Participants with of cortical infarcts 176 (8%) 299 (13%) 123 (5%) with 1 cortical infarct 134 [76%] 189 [63%] 55 [45%] with 2 cortical infarcts 28 [16%] 66 [22%] 38 [31%] with 3 cortical infarcts 10 [6%] 22 [7%] 12 [10%] with 4 cortical infarcts 1 [1%] 7 [2%] 6 [5%] with ≥5 cortical infarcts 3 [2%] 15 [5%] 12 [10%] Data are shown as mean ± SD, or frequency (%). The table shows number of participants with cerebrovascular disease markers and a specification in markers. Number of participants with cerebrovascular disease marker as percentage of the total sample size (in brackets: ( )). Number of participants with a specific cerebrovascular disease markers as percentage of the total number of participants with this cerebrovascular disease marker (in square brackets: [ ]). PVS: perivascular spaces.
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