CONTENTS CHAPTER 1 GENERAL INTRODUCTION 9 CHAPTER 2 DIFFERENT CARDIOVASCULAR RISK FACTORS ARE RELATED TO DISTINCT WHITE MATTER HYPERINTENSITY MRI PHENOTYPES IN OLDER ADULTS 19 CHAPTER 3 WHITE MATTER HYPERINTENSITY SHAPE IS RELATED TO LONG-TERM PROGRESSION OF CEREBROVASCULAR DISEASE IN COMMUNITY-DWELLING OLDER ADULTS 37 CHAPTER 4 A MORE IRREGULAR SHAPE OF WHITE MATTER HYPERINTENSITIES IS ASSOCIATED WITH COGNITIVE DECLINE OVER 5 YEARS IN COMMUNITY-DWELLING OLDER ADULTS 63 CHAPTER 5 WHITE MATTER HYPERINTENSITY SHAPE IS ASSOCIATED WITH LONG-TERM DEMENTIA RISK 83 CHAPTER 6 IDENTIFICATION OF DISTINCT BRAIN MRI PHENOTYPES AND THEIR ASSOCIATION WITH LONG-TERM DEMENTIA RISK IN COMMUNITY-DWELLING OLDER ADULTS 111 CHAPTER 7 STUDY PROTOCOL OF THE WHIMAS: IDENTIFICATION OF NOVEL 7T MRI WHITE MATTER HYPERINTENSITY SHAPE AND BRAIN CLEARANCE MARKERS FOR CEREBRAL SMALL VESSEL DISEASE 141 CHAPTER 8 GENERAL DISCUSSION 161 CHAPTER 9 SUMMARY 169 APPENDICES LIST OF PUBLICATIONS 182 CURRICULUM VITAE 185 ACKNOWLEDGEMENTS 186
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