Jasmin Annica Kuhn-Keller

CHAPTER 1 GENERAL INTRODUCTION	9
CHAPTER 2 DIFFERENT CARDIOVASCULAR RISK FACTORS ARE RELATED TO DISTINCT WHITE MATTER HYPERINTENSITY MRI PHENOTYPES IN OLDER ADULTS	19
CHAPTER 3 WHITE MATTER HYPERINTENSITY SHAPE IS RELATED TO LONG-TERM PROGRESSION OF CEREBROVASCULAR DISEASE IN COMMUNITY-DWELLING OLDER ADULTS	37
CHAPTER 4 A MORE IRREGULAR SHAPE OF WHITE MATTER HYPERINTENSITIES IS ASSOCIATED WITH COGNITIVE DECLINE OVER 5 YEARS IN COMMUNITY-DWELLING OLDER ADULTS	63
CHAPTER 5 WHITE MATTER HYPERINTENSITY SHAPE IS ASSOCIATED WITH LONG-TERM DEMENTIA RISK	83
CHAPTER 6 IDENTIFICATION OF DISTINCT BRAIN MRI PHENOTYPES AND THEIR ASSOCIATION WITH LONG-TERM DEMENTIA RISK IN COMMUNITY-DWELLING OLDER ADULTS	111
CHAPTER 7 STUDY PROTOCOL OF THE WHIMAS: IDENTIFICATION OF NOVEL 7T MRI WHITE MATTER HYPERINTENSITY SHAPE AND BRAIN CLEARANCE MARKERS FOR CEREBRAL SMALL VESSEL DISEASE	141
CHAPTER 8 GENERAL DISCUSSION	161
CHAPTER 9 SUMMARY	169
APPENDICES	180
LIST OF PUBLICATIONS	182
CURRICULUM VITAE	185
ACKNOWLEDGEMENTS	186

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