108 Chapter 4 Table 2. Definition of risk factors on adverse course of SARS-CoV-2 Risk factor Definition Age ≥ 70 year Patients 70 years and older per 1-01-2020 Sex Male gender Obesity, BMI > 29 Body mass index is higher than 29 per 1-01-2020 Smoking Patents with an active or previous smoking status per 1-01-2020 Heart disease* ICPC K74 Angina pectoris ICPC K75 and K76 Myocardial infarct ICPC K77 Heart failure ICPC K78 Atrial fibrillation Diabetes mellitus* ICPC T90 Diabetes mellitus Severe chronic respiratory disease* ICPC R91 Chronic bronchitis ICPC R89 Congenital anomaly respiratory ICPC R91 Bronchiëctasieën ICPC R95 COPD Hiv-infection* ICPC B90 Use of anti-viral medication for a Hiv-infection Severe renal disease* ICPC U99(.01) Renal impairment and eGFR is below 25 ml/min/1.73 m2 Severe liver disease* ICPC D97 Cirrhosis Liver failure of liver decompensation Contra-indication label liver impairment Down syndrome* ICPC A90.(01) Down syndrome BMI: Body mass index. ICPC: International Classification of Primary Care codes 1st edition. Hiv: Human immunodeficient virus. COPD: Chronic Obstructive Pulmonary Disease. eGFR: estimated Glomerular Filtration Rate. *These risk factors were merged into one co-morbidity variable. The presence of each single risk factor/disease was counted as 1 and added together as count variable.
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